In Vitro Thrombolytic and In Vivo Cardioprotective Activities of Methanolic Extract of Indigofera cassioides Rottl. Ex. DC

Indigofera cassioides Rottl. Ex. DC. is a large shrub, distributed throughout the hills of India. Because its reported robust antioxidant potential and phytoconstituents content, we were interested in investigating vitro thrombolytic vivo cardioprotective effect methanolic leaves extract cassioides. An model was used to evaluate clot lysis different concentrations along with streptokinase as positive control distilled water negative control. Cardioprotective activity has been evaluated isoproterenol-induced myocardial infarction rats. The treatment designed four groups six animals each follows. Group I: Control, II: Isoproterenol alone, III: Methanolic (200 mg/kg) IV: (400 mg/kg). To efficacy against damage, biochemical parameters histopathological studies carried out. High-performance thin-layer chromatography fingerprint analysis revealed presence terpenoid flavonoid compounds. shows dose-dependent effect. Isoproterenol-induced exhibited significantly altered lipid profile, alanine transaminase, aspartate alkaline phosphatase also elevate serum cardiac markers creatine phosphokinase-myocardial band lactate dehydrogenase, which reversed near normal levels pre-treatment In conclusion, significant might be an aid reduce infarction. confirmed by reduction marker enzymes, profile protection changes on heart tissues.